Synthesis , Characterization and Antifungal Activity of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4-bromophenyl) -6-bromo-3(h)-quinazolin-4-one and Its Metal Chelates

Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4bromophenyl)-6-bromo-3(H)-quinazolin-4-one ligand called HAMQ (HL11) was studied. To prepare this ligand anthranilic acid was converted into 5-bromo–N-Chloroacetyl anthranilic acid then into 2-[(8-hydroxyquinolinyl) -5-aminomethyl] -3-(4-bromophenyl) 6-Bromo3(H)-quinazolin-4-one. This compound was finally condensed with 5-amino-8hydroxyquinoline. The transition metal complexes of Cu, Ni, Zn, Mn and Co of this ligand HAMQ were prepared and characterized by elemental analysis, IR , NMR and reflectance spectral studies and magnetic measurements. The stoichiometry of the complexes has been found to be 1: 2 (Metal: ligand). The data suggested an octahedral geometry around Co, Ni and Mn complexes, a distorted octahedral geometry around Cu and a tetrahedral geometry around Zn chelates have been proposed. These complexes have been monitored for their antifungal activities.